Long-term PM2.5 exposure disrupts corneal epithelial homeostasis by impairing limbal stem/progenitor cells in humans and rat models

Abstract Background Limbal stem/progenitor cells (LSPCs) play a crucial role in maintaining corneal health by regulating epithelial homeostasis. Although PM2.5 is associated with the occurrence of several corneal diseases, its effects on LSPCs are not clearly understood. Methods In this study, we ex...

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Autori principali:	Shengjie Hao, Zhijian Chen, Yuzhou Gu, Lu Chen, Feiyin Sheng, Yili Xu, Di Wu, Yu Han, Bing Lu, Shuying Chen, Wei Zhao, Houfa Yin, Xiaofeng Wang, S. Amer Riazuddin, Xiaoming Lou, Qiuli Fu, Ke Yao
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2023-09-01
Serie:	Particle and Fibre Toxicology
Soggetti:	Ambient fine particulate matter Limbal stem cells Limbal microenvironments Circadian rhythm
Accesso online:	https://doi.org/10.1186/s12989-023-00540-y
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