Evaluating Known Zika Virus NS2B-NS3 Protease Inhibitor Scaffolds via In Silico Screening and Biochemical Assays

The NS2B-NS3 protease (NS2B-NS3pro) is regarded as an interesting molecular target for drug design, discovery, and development because of its essential role in the Zika virus (ZIKV) cycle. Although no NS2B-NS3pro inhibitors have reached clinical trials, the employment of drug-like scaffolds can faci...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Lucianna H. Santos, Rafael E. O. Rocha, Diego L. Dias, Beatriz M. R. M. Ribeiro, Mateus Sá M. Serafim, Jônatas S. Abrahão, Rafaela S. Ferreira
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-09-01
coleção:	Pharmaceuticals
Assuntos:	biochemical assays NS2B-NS3 protease scaffold similarity virtual screening Zika virus
Acesso em linha:	https://www.mdpi.com/1424-8247/16/9/1319
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!