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γ9δ2 T-Cell Expansion and Phenotypic Profile Are Reflected in the CDR3δ Repertoire of Healthy Adults

γ9δ2T cells fill a distinct niche in human immunity due to the unique physiology of the phosphoantigen-reactive γ9δ2TCR. Here, we highlight reproducible TCRδ complementarity-determining region 3 (CDR3δ) repertoire patterns associated with γ9δ2T cell proliferation and phenotype, thus providing eviden...

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Hoofdauteurs: Anna Vyborova, Anke Janssen, Lucrezia Gatti, Froso Karaiskaki, Austin Yonika, Sanne van Dooremalen, Jasper Sanders, Dennis X. Beringer, Trudy Straetemans, Zsolt Sebestyen, Jürgen Kuball
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2022-07-01
Reeks:Frontiers in Immunology
Onderwerpen:
human γ9δ2 T cells
CDR3δ
adult Vδ2 repertoire
differentiation profile
public clonotypes
NKG2D
Online toegang:https://www.frontiersin.org/articles/10.3389/fimmu.2022.915366/full
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