SARS-CoV-2 infection of human lung epithelial cells induces TMPRSS-mediated acute fibrin deposition

Abstract Severe COVID-associated lung injury is a major confounding factor of hospitalizations and death with no effective treatments. Here, we describe a non-classical fibrin clotting mechanism mediated by SARS-CoV-2 infected primary lung but not other susceptible epithelial cells. This infection-i...

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Auteurs principaux:	Rachel Erickson, Chang Huang, Cameron Allen, Joanna Ireland, Gwynne Roth, Zhongcheng Zou, Jinghua Lu, Bernard A. P. Lafont, Nicole L. Garza, Beniah Brumbaugh, Ming Zhao, Motoshi Suzuki, Lisa Olano, Joseph Brzostowski, Elizabeth R. Fischer, Homer L. Twigg, Reed F. Johnson, Peter D. Sun
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2023-10-01
Collection:	Nature Communications
Accès en ligne:	https://doi.org/10.1038/s41467-023-42140-6
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