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Hepatocyte mARC1 promotes fatty liver disease

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) has a prevalence of ∼25% worldwide, with significant public health consequences yet few effective treatments. Human genetics can help elucidate novel biology and identify targets for new therapeutics. Genetic variants in mitochondrial...

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Principais autores: Lara C. Lewis, Lingyan Chen, L. Shahul Hameed, Robert R. Kitchen, Cyrielle Maroteau, Shilpa R. Nagarajan, Jenny Norlin, Charlotte E. Daly, Iwona Szczerbinska, Sara Toftegaard Hjuler, Rahul Patel, Eilidh J. Livingstone, Tom N. Durrant, Elisabeth Wondimu, Soumik BasuRay, Anandhakumar Chandran, Wan-Hung Lee, Sile Hu, Barak Gilboa, Megan E. Grandi, Enrique M. Toledo, Abdullah H.A. Erikat, Leanne Hodson, William G. Haynes, Natalie W. Pursell, Ken Coppieters, Jan Fleckner, Joanna M.M. Howson, Birgitte Andersen, Maxwell A. Ruby
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-05-01
Serier:JHEP Reports
Fag:
Hepatic steatosis
NASH
Mendelian randomisation
Triglycerides
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589555923000241
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