Exome sequencing shows same pattern of clonal tumor mutational burden, intratumor heterogenicity and clonal neoantigen between autologous tumor and Vigil product

Abstract Retrospective data support overall survival (OS) advantage to high clonal tumor mutation burden (cTMB), high clonal neoantigen load (cNEO) and low intratumor heterogeneity (ITH) in cancer patients who receive immunotherapy. In order to explore this relationship prospectively with Vigil, a t...

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主要な著者:	David Willoughby, Ernest Bognar, Laura Stanbery, Casey Nagel, Gladice Wallraven, Aman Pruthi, Nicholas Bild, Ericca Stamper, Donald Rao, Adam Walter, John Nemunaitis
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2025-03-01
シリーズ:	Scientific Reports
主題:	Clonal tumor mutation burden Intratumor heterogeneity Autologous tumor Tumor mutation burden Neoantigen Vigil
オンライン･アクセス:	https://doi.org/10.1038/s41598-025-90136-7
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