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LncRNA-Fendrr protects against the ubiquitination and degradation of NLRC4 protein through HERC2 to regulate the pyroptosis of microglia

Abstract Objectives Targeted inhibition of inflammatory response can reduce diabetic cerebral ischemia–reperfusion (I/R) injure. Pyroptosis is characterized by caspase-1 dependence and the release of a large number of pro-inflammatory factors. LncRNA-Fendrr is associated with a variety of diseases,...

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שמור ב:
Principais autores: Li-Qing Wang, Yue-Ying Zheng, Heng-Jun Zhou, Xiong-Xin Zhang, Pin Wu, Sheng-Mei Zhu
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2021-04-01
סדרה:Molecular Medicine
נושאים:
Cerebral ischemia–reperfusion
Diabetes
Pyroptosis
LncRNA-Fendrr
NLRC4
HERC2
גישה מקוונת:https://doi.org/10.1186/s10020-021-00299-y
תגים: הוספת תג
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