Interactions between the gut microbiome, associated metabolites and the manifestation and progression of heart failure with preserved ejection fraction in ZSF1 rats

Abstract Background Heart failure with preserved ejection fraction (HFpEF) is associated with systemic inflammation, obesity, metabolic syndrome, and gut microbiome changes. Increased trimethylamine-N-oxide (TMAO) levels are predictive for mortality in HFpEF. The TMAO precursor trimethylamine (TMA)...

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Autori principali:	Salmina J. Guivala, Konrad A. Bode, Jürgen G. Okun, Ece Kartal, Edzard Schwedhelm, Luca V. Pohl, Sarah Werner, Sandra Erbs, Holger Thiele, Petra Büttner
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-08-01
Serie:	Cardiovascular Diabetology
Soggetti:	HFpEF TMAO Intestinal microbiome Inflammation Intestinal barrier FMO3
Accesso online:	https://doi.org/10.1186/s12933-024-02398-6
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