A trans-translation inhibitor that targets ribosomal protein bL12 kills Mycobacterium tuberculosis
ABSTRACT New antibiotics with novel mechanisms of action are needed to treat infections by multidrug-resistant strains of Mycobacterium tuberculosis. Here, we show that KKL-1005, an anti-tubercular triazole-based molecule, binds to ribosomal protein bL12 and specifically inhibits the trans-translati...
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| Principais autores: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2025-10-01
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| Serier: | Journal of Bacteriology |
| Fag: | |
| Online adgang: | https://journals.asm.org/doi/10.1128/jb.00236-25 |
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