Homomultimeric FAP Inhibitor-Based Radioligands for Cancer Theranostics: Design Principles, Structure–Function Relationships, and Preclinical Performance

Fibroblast activation protein (FAP) has emerged as a promising target for the development of cancer radiotheranostics due to its selective overexpression in cancer-associated fibroblasts (CAFs) within the tumor stroma. Affinity and selectivity refer to the binding affinities of FAP inhibitors toward...

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Главные авторы:	Zhiyang Wu, Eleni Gourni, Sanjana Ballal, Pieter Van der Veken, Frank Roesch
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2026-06-01
Серии:	Molecules
Предметы:	homomultimeric FAPI ligands theranostics fibroblast activation protein (FAP) radioligand therapy (RLT) dimerization
Online-ссылка:	https://www.mdpi.com/1420-3049/31/12/2124
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