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Novel 5′-Norcarbocyclic Pyrimidine Derivatives as Antibacterial Agents

A series of novel 5&#8242;-norcarbocyclic derivatives of 5-alkoxymethyl or 5-alkyltriazolyl-methyl uracil were synthesized and the activity of the compounds evaluated against both Gram-positive and Gram-negative bacteria. The growth of <i>Mycobacterium smegmatis</i> was completely inhibited by the m...

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Principais autores: Anastasia L. Khandazhinskaya, Liudmila A. Alexandrova, Elena S. Matyugina, Pavel N. Solyev, Olga V. Efremenkova, Karen W. Buckheit, Maggie Wilkinson, Robert W. Buckheit, Larisa N. Chernousova, Tatiana G. Smirnova, Sofya N. Andreevskaya, Olga G. Leonova, Vladimir I. Popenko, Sergey N. Kochetkov, Katherine L. Seley-Radtke
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2018-11-01
Colecção:Molecules
Assuntos:
5′-norcarbocyclic nucleosides
<i>Mycobacterium tuberculosis</i>
antibacterial activity
uracil derivatives
Acesso em linha:https://www.mdpi.com/1420-3049/23/12/3069
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