Synthesis and new DNA targeting activity of 6- and 7-tert-butylfascaplysins

Abstract Fascaplysin is a red cytotoxic pigment with anticancer properties isolated from the marine sponge Fascaplysinopsis sp. Recently, structure–activity relationship analysis reported by our group suggested that selective cytotoxicity of fascaplysin derivatives towards tumor cells negatively cor...

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Autors principals:	Sergey A. Dyshlovoy, Wael Y. Mansour, Natalia A. Ramm, Jessica Hauschild, Maxim E. Zhidkov, Malte Kriegs, Alexandra Zielinski, Konstantin Hoffer, Tobias Busenbender, Ksenia A. Glumakova, Pavel V. Spirin, Vladimir S. Prassolov, Derya Tilki, Markus Graefen, Carsten Bokemeyer, Gunhild von Amsberg
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2024-05-01
Col·lecció:	Scientific Reports
Matèries:	Fascaplysin Marine compound Synthesis Prostate cancer DNA targeting Natural products
Accés en línia:	https://doi.org/10.1038/s41598-024-62358-8
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