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Proteomic identification of protein radicals from myeloperoxidase-mediated mefenamic acid oxidation reveals a mechanism of NSAID-induced oxidative injury

Mefenamic acid (MFA; Ponstel®, USA) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat inflammatory pain. Despite its effectiveness, it carries an FDA black box warning for serious adverse effects, including hepatotoxicity, agranulocytosis, and gastrointestinal injury. While these toxici...

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Principais autores: Newton H. Tran, Steven Lockhart, Othman Eldalal, Phuong G. Tran, John-Paul R. Cooper, Lusine Tonoyan, Richard P. Fahlman, Arno G. Siraki
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-12-01
coleção:Redox Biochemistry and Chemistry
Assuntos:
Myeloperoxidase
Mefenamic acid
PF-1355
Drug metabolism
Free radicals
Oxidative stress
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2773176625000203
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