Synergistic anticancer effects of cabozantinib and cuproptosis induction driven by DHRS2-KAT2A-H3K27ac axis in clear cell renal cell carcinoma

Abstract Background Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of kidney cancer, representing about 70–80% of all renal cell carcinomas. Cuproptosis, a recently identified mode of cell death, has increasingly been linked to tumor initiation, progression, and drug resistanc...

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Detalhes bibliográficos

Principais autores:	Yilong Cao, Chao Xu, Bowei Zhang, Changbao Qu, Yuepeng Liu, Bei Shi, Xiaoling Li, Jiehan Li, Zeyuan Zhang, Shengtao Dai, Qingyun Sun, Yaxuan Wang, Junfei Gu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-01-01
Colecção:	Biology Direct
Assuntos:	Clear cell renal cell carcinoma (ccRCC) Cabozantinib Cuproptosis DHRS2 KAT2A
Acesso em linha:	https://doi.org/10.1186/s13062-025-00721-z
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