A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABA_A Receptor

Analgesic and anti-inflammatory properties mediated by the κ opioid receptor (KOR) have been reported for oxadiazole imidazodiazepines. Affinities determined by radioligand competition assays of more than seventy imidazodiazepines using cell homogenates from HEK293 cells that overexpress KOR, µ opio...

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Autors principals:	Guanguan Li, Amanda N. Nieman, Md Yeunus Mian, Nicolas M. Zahn, Brandon N. Mikulsky, Michael M. Poe, Kashi R. Methuku, Yongfeng Liu, James M. Cook, Douglas C. Stafford, Leggy A. Arnold
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2020-08-01
Col·lecció:	Molecules
Matèries:	opioid receptor imidazodiazepine GABA<sub>A</sub> receptor
Accés en línia:	https://www.mdpi.com/1420-3049/25/17/3864
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