Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss

Abstract Background Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease (AD), which is closely related to tau pathology and hippocampal impairment. Due to the heterogeneity of brain neurons, the specific roles of different brain neurons in terms of their sensitivity to...

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Detalhes bibliográficos

Principais autores:	Hui-Yang Lei, Gui-Lin Pi, Ting He, Rui Xiong, Jing-Ru Lv, Jia-Le Liu, Dong-Qin Wu, Meng-Zhu Li, Kun Shi, Shi-Hong Li, Na-Na Yu, Yang Gao, Hui-Ling Yu, Lin-Yu Wei, Xin Wang, Qiu-Zhi Zhou, Pei-Lin Zou, Jia-Yang Zhou, Ying-Zhou Liu, Nai-Ting Shen, Jie Yang, Dan Ke, Qun Wang, Gong-Ping Liu, Xi-Fei Yang, Jian-Zhi Wang, Ying Yang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	KeAi Communications Co., Ltd. 2024-03-01
coleção:	Military Medical Research
Assuntos:	Alzheimer’s disease Tau protein Ventral hippocampus Social memory Ursolic acid Transcription factor EB (TFEB)
Acesso em linha:	https://doi.org/10.1186/s40779-024-00512-z
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