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Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI

Abstract Background Prostate cancer tissues are inherently heterogeneous, which presents a challenge for metabolic profiling using traditional bulk analysis methods that produce an averaged profile. The aim of this study was therefore to spatially detect metabolites and lipids on prostate tissue sec...

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Principais autores: Maria K. Andersen, Therese S. Høiem, Britt S. R. Claes, Benjamin Balluff, Marta Martin-Lorenzo, Elin Richardsen, Sebastian Krossa, Helena Bertilsson, Ron M. A. Heeren, Morten B. Rye, Guro F. Giskeødegård, Tone F. Bathen, May-Britt Tessem
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2021-01-01
coleção:Cancer & Metabolism
Assuntos:
Prostate cancer
Metabolism
Mass spectrometry imaging
Tumor heterogeneity
Acesso em linha:https://doi.org/10.1186/s40170-021-00242-z
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