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Epigenetic activation of CD274/PD-L1 by the MSL complex expands its role beyond dosage compensation

IntroductionThe regulation of CD274 (PD-L1), a pivotal immune checkpoint in cancer immunotherapy, remain incompletely understood. The male-specific lethal (MSL) complex, initially identified in Drosophila dosage compensation, contains the core subunit KAT8 (MOF), which catalyzes histone H4 lysine 16...

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Principais autores: Aiping Wen, Xuanfei Feng, Yingying Li, Xueli Cui, Qixian Zou, Yong Cai, Jingji Jin, Yunxiao He
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-12-01
coleção:Frontiers in Immunology
Assuntos:
histone acetyltransferase
CD274
transcriptional regulation
male-specific lethal
H4K16Ac
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1711451/full
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