Privileged Scaffold Hybridization in the Design of Carbonic Anhydrase Inhibitors

Human Carbonic Anhydrases (hCA) are enzymes that contribute to cancer’s development and progression. Isoforms IX and XII have been identified as potential anticancer targets, and, more specifically, hCA IX is overexpressed in hypoxic tumor cells, where it plays an important role in reprogramming the...

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Principais autores:	Daniela Secci, Erica Sanna, Simona Distinto, Alessia Onali, Antonio Lupia, Laura Demuru, Giulia Atzeni, Rita Meleddu, Filippo Cottiglia, Andrea Angeli, Claudiu T. Supuran, Elias Maccioni
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2024-09-01
Series:	Molecules
Assuntos:	carbonic anhydrases inhibitors scaffold hybridization benzenesulfonamide-based zinc binders
Acceso en liña:	https://www.mdpi.com/1420-3049/29/18/4444
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