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Enpatoran, a first-in-class, selective, orally administered toll-like receptor 7/8 inhibitor, in systemic and cutaneous lupus erythematosus: results from a randomised, placebo-controlled phase Ib study

Objective To evaluate multiple-ascending doses of enpatoran, a selective toll-like receptor 7/8 (TLR7/8) inhibitor with the potential to modulate processes central to lupus pathophysiology, in patients with systemic and cutaneous lupus erythematosus (SLE/CLE).Methods In this randomised, double-blind...

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Principais autores: Ruth Fernandez-Ruiz, Torsten Witte, Lena Klopp-Schulze, Jamie Shaw, Flavie Moreau, Joerg Wenzel, Nadezda Abramova, Dominika Weinelt, Deborah Denis
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2025-11-01
Serier:Lupus Science and Medicine
Online adgang:https://lupus.bmj.com/content/12/2/e001705.full
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