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6% Hydroxyethyl starch (HES 130/0.4) diminishes glycocalyx degradation and decreases vascular permeability during systemic and pulmonary inflammation in mice

Abstract Background Increased vascular permeability is a pathophysiological hallmark of sepsis and results in increased transcapillary leakage of plasma fluid, hypovolemia, and interstitial edema formation. 6% hydroxyethyl starch (HES 130/0.4) is commonly used to treat hypovolemia to maintain adequa...

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Principais autores: Andreas Margraf, Jan M. Herter, Katharina Kühne, Anika Stadtmann, Thomas Ermert, Manuel Wenk, Melanie Meersch, Hugo Van Aken, Alexander Zarbock, Jan Rossaint
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-05-01
coleção:Critical Care
Assuntos:
Hydroxyethyl starch 130/0.4
Inflammation
Vascular permeability
Glycocalyx
Sepsis
Acesso em linha:http://link.springer.com/article/10.1186/s13054-017-1846-3
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