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PELI2 inhibits colorectal cancer development through MAPK signaling pathway

Abstract Colorectal cancer is one of the most common malignant tumors worldwide. Colorectal cancer has a poor survival rate because it tends to metastasise to the liver and other organs. PELI2, an E3 ubiquitin ligase, is down-expressed in a variety of tumors. However, the role of PELI2 in colorectal...

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Principais autores: Jialin Liu, Shengyun Hu, Liangbo Zhao, Yanmei Yang, Guanghua Wu, Yimeng Duan, Xinrui Ma, Peiwen Wang, Zhiyong Zhang, Hong Zong
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-06-01
Serier:Molecular Medicine
Fag:
Colorectal cancer
PELI2
MAPK
Tumorigenesis
Online adgang:https://doi.org/10.1186/s10020-025-01294-3
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