VKORC1L1–mediated vitamin K recycling counters ferroptosis to promote endothelial repair

Abstract Vitamin K is classically known for hepatic γ-carboxylation via VKORC1, yet accumulating evidence suggests broader redox-regulatory roles. Here, we characterize the VKORC1 paralogue VKORC1L1 as an anti-oxidative enzyme that couples the vitamin K cycle to ferroptosis defense in the endotheliu...

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Hlavní autoři:	Elena Repges, Adem Aksoy, Katrin J. Czogalla-Nitsche, Andreas Zietzer, Cornelius Müller, Johannes Oldenburg, Sebastian Zimmer, Georg Nickenig, Vedat Tiyerili, Muntadher Al Zaidi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-06-01
Edice:	Scientific Reports
Témata:	Endothelium Ferroptosis Lipid peroxidation Vitamin K VKORC1L1
On-line přístup:	https://doi.org/10.1038/s41598-026-54463-7
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