Generation of a homozygous CRISPR/Cas9-mediated knockout H9 hESC subline for the CRB1 locus
Mutations in the CRB1 gene reportedly cause early-onset autosomal recessive retinitis pigmentosa (RP), which can result in severe loss of vision at an early age. To investigate the mechanism of CRB1-knockout (CRB1-/-) induced RP, we generated a subline of H9 human embryonic stem cells harboring fram...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier
2020-12-01
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| Col·lecció: | Stem Cell Research |
| Accés en línia: | http://www.sciencedirect.com/science/article/pii/S1873506120303585 |
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