Enhancing Stability and Bioavailability of Peptidylglycine Alpha-Amidating Monooxygenase in Circulation for Clinical Use

Peptidylglycine alpha-amidating monooxygenase (PAM) is the only enzyme known to catalyze C-terminal amidation, a final post-translational modification step essential for the biological activity of over 70 bioactive peptides, including adrenomedullin (ADM), calcitonin gene-related peptide (CGRP), amy...

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Bibliografische gegevens

Hoofdauteurs:	Yulia Ilina, Paul Kaufmann, Michaela Press, Theo Ikenna Uba, Andreas Bergmann
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	MDPI AG 2025-02-01
Reeks:	Biomolecules
Onderwerpen:	peptidylglycine alpha-amidating monooxygenase C-terminal amidation peptide hormones pharmacokinetics half-life extension
Online toegang:	https://www.mdpi.com/2218-273X/15/2/224
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