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Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation

The tumor microenvironment is a critical modulator of carcinogenesis; however, in many tumor types, the influence of the stroma during preneoplastic stages is unknown. Here we explored the relationship between pre-tumor cells and their surrounding stroma in malignant progression of the cerebellar tu...

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Principais autores: Erin A Bassett, Nicholas Tokarew, Ema A Allemano, Chantal Mazerolle, Katy Morin, Alan J Mears, Brian McNeill, Randy Ringuette, Charles Campbell, Sheila Smiley, Neno T Pokrajac, Adrian M Dubuc, Vijay Ramaswamy, Paul A Northcott, Marc Remke, Philippe P Monnier, David Potter, Kim Paes, Laura L Kirkpatrick, Kenneth J Coker, Dennis S Rice, Carol Perez-Iratxeta, Michael D Taylor, Valerie A Wallace
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2016-11-01
Colecção:eLife
Assuntos:
Medulloblastoma
Patched
Hedgehog
Norrin
Frizzled4
stroma
Acesso em linha:https://elifesciences.org/articles/16764
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