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DNA strand breaks and gaps target retroviral intasome binding and integration

Abstract Retrovirus integration into a host genome is essential for productive infections. The integration strand transfer reaction is catalyzed by a nucleoprotein complex (Intasome) containing the viral integrase (IN) and the reverse transcribed (RT) copy DNA (cDNA). Previous studies suggested that...

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Bibliografiske detaljer
Principais autores: Gayan Senavirathne, James London, Anne Gardner, Richard Fishel, Kristine E. Yoder
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2023-11-01
Serier:Nature Communications
Online adgang:https://doi.org/10.1038/s41467-023-42641-4
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