High-depth whole genome sequencing of premalignant breast lesions reveals rearrangement hotspots and personalized management opportunities

Abstract Ductal carcinoma in situ is a non-obligate precursor lesion of breast cancer. Often detected by mammography, most cases are managed through surgical and/or radiotherapy approaches. Today, it is not possible to predict which patients will progress to invasive disease. Here, we evaluate high-...

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Autori principali:	Lucia Chmelova, Helen R. Davies, Andrea Degasperi, Giuseppe Rinaldi, Leon Wils, Daniella Black, Yasin Memari, Gene C. C. Koh, Scott Shooter, Lennart Mulder, Petra Kristel, Karoly Szuhai, Gino Prasad, Ivy Tsz-Lo Wong, Jens Luebeck, Yogesh Kumar, Jan Czarnecki, Shadi Basyuni, Zoya Kingsbury, Mark T. Ross, Øystein Garred, Margit Riis, Karin T. Lande, Johan Vallon-Christersson, Anna Ehinger, Amit Agrawal, Stuart A. McIntosh, Vineet Bafna, Paul S. Mischel, Grand Challenges PRECISION Consortium, Jelle Wesseling, Johan Staaf, Therese Sørlie, Esther H. Lips, Serena Nik-Zainal
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-05-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-026-72952-1
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