Uncoupled nitric oxide synthase activity promotes colorectal cancer progression

Increased levels of reactive oxygen/nitrogen species are one hallmark of chronic inflammation contributing to the activation of pro-inflammatory/proliferative pathways. In the cancers analyzed, the tetrahydrobiopterin:dihydrobiopterin ratio is lower than that of the corresponding normal tissue, lead...

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Principais autores:	Asim Alam, Steven C. Smith, Sundaresan Gobalakrishnan, Mina McGinn, Vasily A. Yakovlev, Christopher S. Rabender
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2023-03-01
Series:	Frontiers in Oncology
Assuntos:	colorectal cancer nitric oxide synthase reactive oxygen species reactive nitrogen species tetrahydrobiopterin
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1165326/full
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