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Sustained localized delivery of immunotherapy to lymph nodes reverses immunosuppression and increases long-term survival in murine glioblastoma

Introduction Despite the advent of immunotherapy as a promising therapeutic, glioblastoma (GBM) remains resistant to using checkpoint blockade due to its highly immunosuppressive tumor milieu. Moreover, current anti-PD-1 treatment requires multiple infusions with adverse systemic effects. Therefore,...

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Hlavní autoři: John Choi, Ayush Pant, Ravi Medikonda, Young-Hoon Kim, Denis Routkevitch, Laura Saleh, Luqing Tong, Hok Yee Chan, Jessie Nedrow, Christopher Jackson, Christina Jackson, Michael Lim
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis Group 2021-01-01
Edice:OncoImmunology
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On-line přístup:http://dx.doi.org/10.1080/2162402X.2021.1940673
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