Serum profiling of uPA, PAI-1, and suPAR in systemic sclerosis: a preliminary study on analytical aspects and associations with microvascular and fibrotic manifestations

IntroductionIn systemic sclerosis (SSc), the laboratory panel lacks biomarkers able to predict the disease course and/or reflect the fibrotic activity in the skin and internal organs. We assessed the association of the serum levels of urokinase (urokinase plasminogen activator, uPA), plasminogen act...

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Autori principali:	Filomena Napolitano, Ilaria Mormile, Gabriele Mignogna, Amato de Paulis, Francesca Wanda Rossi, Nunzia Montuori
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-12-01
Serie:	Frontiers in Immunology
Soggetti:	urokinase plasminogen activator inhibitor-1 soluble urokinase plasminogen activator systemic sclerosis fibrosis microvascular abnormalities
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1697785/full
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