Single-round infectious rotaviruses with deletions of VP7 or VP4 genes, based on SA11 and WC3 strain backbones, and their potential use as viral vectors.

Single-round infectious rotavirus, which lacks a gene essential for virion assembly, serves not only as a safe and effective rotavirus vaccine but also as an orally-administrable viral vector vaccine that induces mucosal immunity. Previously, we generated a single-round infectious rotavirus by parti...

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Detalhes bibliográficos

Principais autores:	Tomohiro Kotaki, Yuta Kanai, Megumi Onishi, Yusuke Sakai, Daisuke Motooka, Zelin Chen, Yasutaka Enoki, Sayuri Komatsu, Katsuhisa Hirai, Shohei Minami, Takahiro Kawagishi, Hiroshi Ushijima, Takeshi Kobayashi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2025-09-01
coleção:	PLoS Pathogens
Acesso em linha:	https://doi.org/10.1371/journal.ppat.1013484
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