The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding

Kinesin-5 motors organize mitotic spindles by sliding apart microtubules. They are homotetramers with dimeric motor and tail domains at both ends of a bipolar minifilament. Here, we describe a regulatory mechanism involving direct binding between tail and motor domains and its fundamental role in mi...

Полное описание

Библиографические подробности

Главные авторы:	Tatyana Bodrug, Elizabeth M Wilson-Kubalek, Stanley Nithianantham, Alex F Thompson, April Alfieri, Ignas Gaska, Jennifer Major, Garrett Debs, Sayaka Inagaki, Pedro Gutierrez, Larisa Gheber, Richard J McKenney, Charles Vaughn Sindelar, Ronald Milligan, Jason Stumpff, Steven S Rosenfeld, Scott T Forth, Jawdat Al-Bassam
Формат:	Artigo
Язык:	Inglês
Опубликовано:	eLife Sciences Publications Ltd 2020-01-01
Серии:	eLife
Предметы:	kinesin-5 motor protein Microtubule sliding mitosis mitotic spindle
Online-ссылка:	https://elifesciences.org/articles/51131
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!