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Nucleoside Reverse Transcriptase Inhibitor Exposure Is Associated with Lower Alzheimer’s Disease Risk: A Retrospective Cohort Proof-of-Concept Study

Brain somatic gene recombination (SGR) and the endogenous reverse transcriptases (RTs) that produce it have been implicated in the etiology of Alzheimer’s disease (AD), suggesting RT inhibitors as novel prophylactics or therapeutics. This retrospective, proof-of-concept study evaluated the incidence...

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Principais autores: Tiffany W. Chow, Mark Raupp, Matthew W. Reynolds, Siying Li, Gwendolyn E. Kaeser, Jerold Chun
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-03-01
Serier:Pharmaceuticals
Fag:
Alzheimer’s disease
human immunodeficiency virus
nucleoside reverse transcriptase inhibitor
protease inhibitor
reverse transcriptase
reverse transcriptase inhibitor
Online adgang:https://www.mdpi.com/1424-8247/17/4/408
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