The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages.

Ovarian tumor domain containing proteases cleave ubiquitin (Ub) and ubiquitin-like polypeptides from proteins. Here we report the crystal structure of human otubain 2 (OTUB2) in complex with a ubiquitin-based covalent inhibitor, Ub-Br2. The ubiquitin binding mode is oriented differently to how viral...

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Bibliografische gegevens

Hoofdauteurs:	Mikael Altun, Thomas S Walter, Holger B Kramer, Patrick Herr, Alexander Iphöfer, Johan Boström, Yael David, Alia Komsany, Nicola Ternette, Ami Navon, David I Stuart, Jingshan Ren, Benedikt M Kessler
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Public Library of Science (PLoS) 2015-01-01
Reeks:	PLoS ONE
Online toegang:	https://doi.org/10.1371/journal.pone.0115344
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