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Validation of NBD-coupled taurocholic acid for intravital analysis of bile acid transport in liver and kidney of mice

Fluorophore-coupled bile acids (BA) represent an important tool for intravital analysis of BA flux in animal models of cholestatic diseases. However, addition of a fluorophore to a BA may alter transport properties. We developed and validated a 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole-coupled tauroc...

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Principais autores: Ahmed Ghallab, Sebastian Kunz, Celine Drossel, Veronica Billo, Adrian Friebel, Mats Georg, Richard Göttlich, Zaynab Hobloss, Reham Hassan, Maiju Myllys, Abdel-latief Seddek, Noha Abdelmageed, Paul A. Dawson, Erik Lindström, Stefan Hoehme, Jan G. Hengstler, Joachim Geyer
Formato: Artigo
Idioma:Inglês
Publicado em: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund 2024-10-01
coleção:EXCLI Journal : Experimental and Clinical Sciences
Assuntos:
Ntcp
OATP
ASBT
cholestasis
cholemic nephropathy
Acesso em linha:https://www.excli.de/excli/article/view/7707
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