Methodologies and Challenges for CRISPR/Cas9 Mediated Genome Editing of the Mammalian Brain

Neurons and glia are highly polarized cells with extensive subcellular structures extending over large distances from their cell bodies. Previous research has revealed elaborate protein signaling complexes localized within intracellular compartments. Thus, exploring the function and the localization...

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Autors principals:	Hirofumi Nishizono, Ryohei Yasuda, Tal Laviv
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2020-11-01
Col·lecció:	Frontiers in Genome Editing
Matèries:	HITI (homology-independent targeted integration) SLENDR (single-cell labeling of endogenous proteins with homology-directed repair) iGONAD (improved-genome editing via oviductal nucleic acids delivery) HDR (homology-directed repair) NHEJ (non-homologous end joining)
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fgeed.2020.602970/full
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