A Nonhomologous End-joining Pathway Is Required for Protein Phosphatase 2A Promotion of DNA Double-Strand Break Repair
Protein phosphatase 2A (PP2A) functions as a potent tumor suppressor, but its mechanism(s) remains enigmatic. Specific disruption of PP2A by either expression of SV40 small tumor antigen or depletion of endogenous PP2A/C by RNA interference inhibits Ku DNA binding and DNA-PK activities, which result...
Salvato in:
| Autori principali: | , , , , |
|---|---|
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2009-10-01
|
| Serie: | Neoplasia: An International Journal for Oncology Research |
| Accesso online: | http://www.sciencedirect.com/science/article/pii/S1476558609800043 |
| Tags: |
Nessun Tag, puoi essere il primo ad aggiungerne!!
|