Reduction of spermine synthase enhances autophagy to suppress Tau accumulation

Abstract Precise polyamine metabolism regulation is vital for cells and organisms. Mutations in spermine synthase (SMS) cause Snyder–Robinson intellectual disability syndrome (SRS), characterized by significant spermidine accumulation and autophagy blockage in the nervous system. Emerging evidence c...

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Autors principals:	Xianzun Tao, Jiaqi Liu, Zoraida Diaz-Perez, Jackson R. Foley, Ashley Nwafor, Tracy Murray Stewart, Robert A. Casero, R. Grace Zhai
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2024-05-01
Col·lecció:	Cell Death and Disease
Accés en línia:	https://doi.org/10.1038/s41419-024-06720-8
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