Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein.

The spike protein receptor-binding domain (RBD) of SARS-CoV-2 is the molecular target for many vaccines and antibody-based prophylactics aimed at bringing COVID-19 under control. Such a narrow molecular focus raises the specter of viral immune evasion as a potential failure mode for these biomedical...

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Principais autores:	Debra Van Egeren, Alexander Novokhodko, Madison Stoddard, Uyen Tran, Bruce Zetter, Michael Rogers, Bradley L Pentelute, Jonathan M Carlson, Mark Hixon, Diane Joseph-McCarthy, Arijit Chakravarty
格式:	Artigo
語言:	Inglês
出版:	Public Library of Science (PLoS) 2021-01-01
叢編:	PLoS ONE
在線閱讀:	https://doi.org/10.1371/journal.pone.0250780
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