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Intracellular Ca2+ is not essential for SHH signaling but is promoted by Shh ligand in embryonic fibroblasts

Abstract Background Sonic Hedgehog (SHH) signaling pathway controls cell proliferation, differentiation, and organ formation. The changes in Ca2+ and their regulatory role in the context of activated SHH signaling have not been fully examined. Results In this study, we induced activation of the SHH...

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書誌詳細
主要な著者: Xuanming Shi, Zhaomin Wang, Shupeng Li, Yiming Pan, Bing Shen, Shuzhen Liu
フォーマット: Artigo
言語:Inglês
出版事項: BMC 2026-01-01
シリーズ:BMC Molecular and Cell Biology
主題:
オンライン・アクセス:https://doi.org/10.1186/s12860-026-00567-x
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