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The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε

African swine fever virus (ASFV), a large and complex cytoplasmic double-stranded DNA virus, has developed multiple strategies to evade the antiviral innate immune responses. Cytosolic DNA arising from invading ASFV is mainly detected by the cyclic GMP-AMP synthase (cGAS) and then triggers a series...

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Збережено в:
Автори: Jia Luo, Jiajia Zhang, Jinghua Ni, Sen Jiang, Nengwen Xia, Yiwen Guo, Qi Shao, Qi Cao, Wanglong Zheng, Nanhua Chen, Quan Zhang, Hongjun Chen, Qing Chen, Hongfei Zhu, François Meurens, Jianzhong Zhu
Формат: Artigo
Мова:Inglês
Опубліковано: Taylor & Francis Group 2022-12-01
Серія:Virulence
Предмети:
ASFV
pS273R
cGAS
STING
IKKε
type I interferons (IFNs)
Онлайн доступ:https://www.tandfonline.com/doi/10.1080/21505594.2022.2065962
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