ATP-fueled STING activation of manganese coordinated nanoagonist to boost antitumor immunity

The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway represents a central driver of innate immune activation, and manganese ion (Mn2+) has recently been identified as a potent modulator of this signaling axis. However, the application of Mn2+ is limited by its rapid cleara...

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Autori principali:	Si-Yao Han, Sui-Juan Zheng, Jia-Qi Luo, Hui-Han Yu, Xiao-Yue Liu, Jin-Zhi Du
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	KeAi Communications Co., Ltd. 2026-07-01
Serie:	Bioactive Materials
Soggetti:	Adenosine triphosphate Cancer metalloimmunotherapy cGAS-STING activation Coordination nanoparticles Manganese ions
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2452199X26000733
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