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IP-10 acts early in CV-A16 infection to induce BBB destruction and promote virus entry into the CNS by increasing TNF-α expression

The mechanisms underlying pathological changes in the central nervous system (CNS) following Coxsackievirus A16 (CV-A16) infection have not yet been elucidated. IFN-γ-inducible protein-10 (IP-10) is often used as a predictive factor to monitor early virus infection. It has also been reported that IP...

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Principais autores: Yajie Hu, Yunguang Hu, Anguo Yin, Yaming Lv, Jiang Li, Jingyuan Fan, Baojiang Qian, Jie Song, Yunhui Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-11-01
Serier:Frontiers in Immunology
Fag:
hand foot and mouth disease (HFMD)
coxsackievirus A16 (CV-A16)
IFN-γ-inducible protein-10 (IP-10)
blood-brain barrier (BBB)
neuroinflammation
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1374447/full
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