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Deciphering the mitochondria–gut microbiota axis in irritable bowel syndrome: pathogenic insights and therapeutic frontiers

Abstract Background Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder involving multiple pathogenic mechanisms. Gut microbiota dysbiosis and mitochondrial dysfunction are key drivers of IBS, as they weaken the intestinal barrier, promote inflammation, and alter metabolism. Howeve...

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Principais autores: Lifang Zeng, Wenpeng Zhou
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-03-01
Serier:Journal of Translational Medicine
Fag:
Mitochondria
Gut microbiota
Irritable bowel syndrome
Pathogenesis
Therapy
Online adgang:https://doi.org/10.1186/s12967-026-07894-9
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