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Distinct Roles of Extracellular Domains in the Epstein-Barr Virus-Encoded BILF1 Receptor for Signaling and Major Histocompatibility Complex Class I Downregulation

ABSTRACT The Epstein-Barr virus (EBV) BILF1 gene encodes a constitutively active G protein-coupled receptor (GPCR) that downregulates major histocompatibility complex (MHC) class I and induces signaling-dependent tumorigenesis. Different BILF1 homologs display highly conserved extracellular loops (E...

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Main Authors: Suzan Fares, Katja Spiess, Emma T. B. Olesen, Jianmin Zuo, Sarah Jackson, Thomas N. Kledal, Mark R. Wills, Mette M. Rosenkilde
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019-02-01
Series:mBio
Subjects:
EBV-BILF1
Epstein-Barr virus
GPCR
major histocompatibility complex
signaling
tumor immunology
Online Access:https://journals.asm.org/doi/10.1128/mBio.01707-18
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