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An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases

Malate and lactate dehydrogenases (MDH and LDH) are homologous, core metabolic enzymes that share a fold and catalytic mechanism yet possess strict specificity for their substrates. In the Apicomplexa, convergent evolution of an unusual LDH from MDH produced a difference in specificity exceeding 12...

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Main Authors: Jeffrey I Boucher, Joseph R Jacobowitz, Brian C Beckett, Scott Classen, Douglas L Theobald
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications Ltd 2014-06-01
Series:eLife
Subjects:
ancestral sequence reconstruction
molecular evolution
specificity
gene duplication
promiscuity
dehydrogenase
Online Access:https://elifesciences.org/articles/02304
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