Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC

IntroductionHepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. Despite significant progress in systemic and immune-based therapies, many patients develop resistance or fail to respond, highlighting the need f...

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Κύριοι συγγραφείς:	Lina Ouologuem, Anna Kübler, Sarah Ouologuem, Amar Hadzic, Jan B. Stöckl, Anna Chiara Siciliano, Stefania Forciniti, Salvatore Nigro, Helena Iuele, Valentina Onesto, Anny Nguyen, Dana Matzek, Carla Abrahamian, Christian Grimm, Bastian Popper, Giuseppe Gigli, Loretta L. del Mercato, Olivia M. Merkel, Thomas Fröhlich, Sebastian Theurich, Karin Bartel
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2025-10-01
Σειρά:	Frontiers in Immunology
Θέματα:	lysosomal ion channels HCC immune evasion TPC2 cancer MAPK signalling
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1668066/full
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