Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome

Abstract Background Focal adhesion signaling involving receptor tyrosine kinases (RTK) and integrins co-controls cancer cell survival and therapy resistance. However, co-dependencies between these receptors and therapeutically exploitable vulnerabilities remain largely elusive in HPV-negative head a...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Felix Broghammer, Irina Korovina, Mahesh Gouda, Martina Celotti, Johan van Es, Inga Lange, Cornelia Brunner, Jovan Mircetic, Robert P. Coppes, Olivier Gires, Andreas Dahl, Michael Seifert, Nils Cordes
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-02-01
coleção:	Molecular Cancer
Assuntos:	HNSCC Fibroblast growth factor receptor Epithelial-to-mesenchymal transition Epidermal growth factor receptor Radiosensitization Radioprotection
Acesso em linha:	https://doi.org/10.1186/s12943-024-01954-8
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!