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Heterologous Ad26/Ad5 adenovirus-vectored vaccines elicited SARS-CoV-2-specific antibody responses with potent Fc activities

IntroductionAntibodies against the SARS-CoV-2 spike protein are a critical immune determinant for protection against the virus. While virus neutralization is a key function of spike-specific antibodies, antibodies also mediate Fc-dependent activities that can play a role in protection or pathogenesi...

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Principais autores: Jéromine Klingler, Shreyas Kowdle, Juan C. Bandres, Rozita Emami-Gorizi, Raymond A. Alvarez, Priyanka G. Rao, Fatima Amanat, Charles Gleason, Giulio Kleiner, Viviana Simon, Alexis Edelstein, Claudia Perandones, Chitra Upadhyay, Benhur Lee, Catarina E. Hioe
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-05-01
coleção:Frontiers in Immunology
Assuntos:
COVID-19
vaccines
adaptive immunity
immunoglobulins
antibodies
Fc functions
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1382619/full
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